Acanthosis And Hyperkeratosis

Hyperkeratosis, associated with other abnormalities in the skin biopsy, can be a key to the final histological diagnosis. Epidermal hypertrophy is a benign alteration of the skin that presents with acanthosis (increased thickness of the keratinocyte layers) and hyperkeratosis.

Acanthosis and hyperkeratosis, usually orthokeratosis, are the hallmarks of frictional keratosis. The keratin may become ragged and delaminated by the patient’s habit, and it is not unusual to find bacterial colonies lodged in surface irregularities.