Before we go on to look at Acanthosis Nigricans Cancer, let us know what Acanthosis Nigricans is.
Acanthosis nigricans (AN) is a skin condition characterized by abnormally increased coloration (hyperpigmentation) and “velvety” thickening (hyperkeratosis) of the skin, particularly of skin fold regions, such as of the neck and groin and under the arms (axillae).
Now let us see what the topic is entails:
Acanthosis Nigricans Cancer
Several Acanthosis Nigricans Cancer benign (non-cancerous) forms of AN have been identified, in which the disorder may be inherited as a primary condition or be associated with other underlying syndromes, an excess accumulation of body fat (obesity), or the use of certain medications (i.e., drug-induced AN). In some cases, AN may occur in conjunction with an underlying cancerous tumor (i.e., malignant AN).
In some instances, AN occurs in association with an underlying cancerous tumor. Known as “malignant AN,” this form of the condition is most common in adults, particularly those over age 40, and appears to affect men and women relatively equally. The underlying malignancy is often derived from glandular tissue (adenocarcinoma), particularly of the stomach (gastric adenocarcinoma), or, less commonly, the intestines, pancreas, uterus, lung, ovary, bladder, breast, or prostate. Rarely, AN may occur in association with malignancy of the lymphatic system (lymphoma).
The medically related factors of AN include diabetes. Obesity, which leads to diabetes and other endocrine disorders, is also a medically related cause. Certain drugs such as human growth hormone or oral contraceptives can be a cause. Lymphoma or cancers of the gastrointestinal or genitourinary tract have been known to bring on severe cases of AN.